Ryanodine Receptor Permeation and Gating
نویسندگان
چکیده
Schneider (1999) recently addressed the question of whether Ca 2 1 sparks arise from the opening of a single ryanodine receptor (RyR) channel or the simultaneous opening of several channels. The discussion highlighted the importance of single RyR channel permeation and gating in the interpretation of Ca 2 1 spark data. The Schneider (1999) perspective inspired us to extend this theoretical discussion by using a published kinetic model of modal RyR gating to actually simulate RyR channel gating and permeation that may underlie a Ca 2 1 spark in cardiac muscle.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of General Physiology
دوره 114 شماره
صفحات -
تاریخ انتشار 1999